ea0063p1026 | Interdisciplinary Endocrinology 2 | ECE2019
Vassiliadi Dimitra Argyro
, Vassiliou Alice
, Stamogiannos G
, Floros G
, Botoula Efthymia
, Jahaj Edison
, Tzanela Marinella
, Orfanos Stylianos E.
, Kotanidou Anastasia
, Dimopoulou Ioanna
, Tsagarakis Stylianos
Purpose: HPA axis activation resulting in increased cortisol production by the adrenals is a crucial part of the response to critical illness. The action of cortisol may also be modulated at the tissue level, through changes in the availability of the free fraction and modifications of the glucocorticoid receptor activity. It has been proposed that tissue resistance to glucocorticoids may occur, at least in some patients, and relate to insufficient anti-inflammatory activity a...